Development, testing and validation of a targeted NGS-panel for the detection of actionable mutations in lung cancer (NSCLC) using anchored multiplex PCR technology in a multicentric setting

• Main Authors: Jörg Kumbrink (Author), Melanie-Christin Demes (Author), Jan Jeroch (Author), Andreas Bräuninger (Author), Kristin Hartung (Author), Uwe Gerstenmaier (Author), Ralf Marienfeld (Author), Axel Hillmer (Author), Nadine Bohn (Author), Christina Lehning (Author), Ferdinand Ferch (Author), Peter Wild (Author), Stefan Gattenlöhner (Author), Peter Möller (Author), Frederick Klauschen (Author), Andreas Jung (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lung cancer is a paradigm for a genetically driven tumor. A variety of drugs were developed targeting specific biomarkers requiring testing for tumor genetic alterations in relevant biomarkers. Different next-generation sequencing technologies are available for library generation: 1) anchored multip...