K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder

SUMMARY The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a 'driver' of UCC, we targeted the expression of mutated Fgfr3 to the murine urothel...

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Main Authors: Imran Ahmad (Author), Lukram Babloo Singh (Author), Mona Foth (Author), Carol-Ann Morris (Author), Makoto Mark Taketo (Author), Xue-Ru Wu (Author), Hing Y. Leung (Author), Owen J. Sansom (Author), Tomoko Iwata (Author)
Format: Book
Published: The Company of Biologists, 2011-07-01T00:00:00Z.
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3rd Floor Main Library

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