Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione

• Main Authors: Takeshi Yokoyama (Author), Shun Takaki (Author), Keisuke Chosa (Author), Takashi Sato (Author), Mary Ann Suico (Author), Yuriko Teranishi (Author), Tsuyoshi Shuto (Author), Mineyuki Mizuguchi (Author), Hirofumi Kai (Author)
• Format: Book
• Published: Elsevier, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Familial amyloid polyneuropathy (FAP) is a genetic, adult-onset, neurodegenerative disorder caused by amyloid formation of transthyretin (TTR), a thyroxine-binding protein. Mutation in TTR causes a propensity of TTR tetramer to dissociate to monomer, which is the first step to amyloidosis. Thus, a d...