Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting

• Main Authors: Tsutomu Shimada (Author), Daisuke Kawakami (Author), Arimi Fujita (Author), Rintaro Yamamoto (Author), Satoshi Hara (Author), Kiyoaki Ito (Author), Ichiro Mizushima (Author), Shinji Kitajima (Author), Yasunori Iwata (Author), Norihiko Sakai (Author), Mitsuhiro Kawano (Author), Takashi Wada (Author), Yoshimichi Sai (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Therapeutic drug monitoring (TDM) systems generally use either liquid chromatography/tandem mass spectrometry (LC-MS/MS) or immunoassay, though both methodologies have disadvantages. In this study, we aimed to evaluate whether a CLAM-LC-MS/MS system, which consists of a sample pr...