The Binding Effect of Proteins on Medications and Its Impact on Electrochemical Sensing: Antipsychotic Clozapine as a Case Study

• Main Authors: George E. Banis (Author), Thomas Winkler (Author), Patricia Barton (Author), Sheryl E. Chocron (Author), Eunkyoung Kim (Author), Deanna L. Kelly (Author), Gregory F. Payne (Author), Hadar Ben-Yoav (Author), Reza Ghodssi (Author)
• Format: Book
• Published: MDPI AG, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clozapine (CLZ), a dibenzodiazepine, is demonstrated as the optimal antipsychotic for patients suffering from treatment-resistant schizophrenia. Like many other drugs, understanding the concentration of CLZ in a patient's blood is critical for managing the patients' symptoms, side effects,...