Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

• Prif Awduron: Anna L. Lahti (Awdur), Ville J. Kujala (Awdur), Hugh Chapman (Awdur), Ari-Pekka Koivisto (Awdur), Mari Pekkanen-Mattila (Awdur), Erja Kerkelä (Awdur), Jari Hyttinen (Awdur), Kimmo Kontula (Awdur), Heikki Swan (Awdur), Bruce R. Conklin (Awdur), Shinya Yamanaka (Awdur), Olli Silvennoinen (Awdur), Katriina Aalto-Setälä (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: The Company of Biologists, 2012-03-01T00:00:00Z.
• Pynciau: article
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SUMMARY Long QT syndrome (LQTS) is caused by functional alterations in cardiac ion channels and is associated with prolonged cardiac repolarization time and increased risk of ventricular arrhythmias. Inherited type 2 LQTS (LQT2) and drug-induced LQTS both result from altered function of the hERG cha...