Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

• Main Authors: Anna L. Lahti (Author), Ville J. Kujala (Author), Hugh Chapman (Author), Ari-Pekka Koivisto (Author), Mari Pekkanen-Mattila (Author), Erja Kerkelä (Author), Jari Hyttinen (Author), Kimmo Kontula (Author), Heikki Swan (Author), Bruce R. Conklin (Author), Shinya Yamanaka (Author), Olli Silvennoinen (Author), Katriina Aalto-Setälä (Author)
• Format: Book
• Published: The Company of Biologists, 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Long QT syndrome (LQTS) is caused by functional alterations in cardiac ion channels and is associated with prolonged cardiac repolarization time and increased risk of ventricular arrhythmias. Inherited type 2 LQTS (LQT2) and drug-induced LQTS both result from altered function of the hERG cha...