The Synovium Attenuates Cartilage Degeneration in KOA through Activation of the Smad2/3-Runx1 Cascade and Chondrogenesis-related miRNAs

• Main Authors: Xiaoyi Zhao (Author), Fangang Meng (Author), Shu Hu (Author), Zibo Yang (Author), Hao Huang (Author), Rui Pang (Author), Xingzhao Wen (Author), Yan Kang (Author), Zhiqi Zhang (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Knee osteoarthritis (KOA) is a highly prevalent disabling joint disease in aged people. Progressive cartilage degradation is the hallmark of KOA, but its deeper mechanism remains unclear. Substantial evidence indicates the importance of the synovium for joint homeostasis. The present study aimed to...