Genome scale analysis of pathogenic variants targetable for single base editing

Abstract Background Single nucleotide variants account for approximately 90% of all known pathogenic variants responsible for human diseases. Recently discovered CRISPR/Cas9 base editors can correct individual nucleotides without cutting DNA and inducing double-stranded breaks. We aimed to find all...

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Principais autores: Alexander V. Lavrov (Autor), Georgi G. Varenikov (Autor), Mikhail Yu Skoblov (Autor)
Formato: Livro
Publicado em: BMC, 2020-09-01T00:00:00Z.
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