Genome scale analysis of pathogenic variants targetable for single base editing

• Principais autores: Alexander V. Lavrov (Autor), Georgi G. Varenikov (Autor), Mikhail Yu Skoblov (Autor)
• Formato: Livro
• Publicado em: BMC, 2020-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Single nucleotide variants account for approximately 90% of all known pathogenic variants responsible for human diseases. Recently discovered CRISPR/Cas9 base editors can correct individual nucleotides without cutting DNA and inducing double-stranded breaks. We aimed to find all...