Conditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma

• Main Authors: Vanessa B. Martino (Author), Thomas Sabljic (Author), Paula Deschamps (Author), Rebecca M. Green (Author), Monica Akula (Author), Erica Peacock (Author), Alexander Ball (Author), Trevor Williams (Author), Judith A. West-Mays (Author)
• Format: Book
• Published: The Company of Biologists, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anterior segment dysgenesis (ASD) encompasses a group of developmental disorders in which a closed angle phenotype in the anterior chamber of the eye can occur and 50% of patients develop glaucoma. Many ASDs are thought to involve an inappropriate patterning and migration of the periocular mesenchym...