Inhibition of Microbiota-dependent Trimethylamine N-Oxide Production Ameliorates High Salt Diet-Induced Sympathetic Excitation and Hypertension in Rats by Attenuating Central Neuroinflammation and Oxidative Stress

• 主要な著者: Gang Liu (著者), Jiayin Cheng (著者), Tianhao Zhang (著者), Yingxin Shao (著者), Xiangxu Chen (著者), Lihong Han (著者), Ru Zhou (著者), Bin Wu (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Excessive dietary salt intake induces neuroinflammation and oxidative stress in the brain, which lead to sympathetic excitation, contributing to hypertension. However, the underlying mechanisms remain elusive. Accumulating evidence reveals that trimethylamine-N-oxide (TMAO), a gut microbiota-derived...