Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects

Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects

Objective: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) possess multiple bioactive isoforms that are rendered non-insulinotropic by the enzyme dipeptidyl peptidase-4 (DPP-4). Recently, some ELISA kits have been developed to specifically measure "active&...

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Main Authors: Tsuyoshi Yanagimachi (Author), Yukihiro Fujita (Author), Yasutaka Takeda (Author), Jun Honjo (Author), Hidemitsu Sakagami (Author), Hiroya Kitsunai (Author), Yumi Takiyama (Author), Atsuko Abiko (Author), Yuichi Makino (Author), Timothy J. Kieffer (Author), Masakazu Haneda (Author)
Format: Book
Published: Elsevier, 2017-02-01T00:00:00Z.
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