Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study

Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study

ABSTRACTStudies in genetically modified animals and human genetics have recently provided new insight into the role of voltage-gated L-type Ca2+ channels in human disease. Therefore, the inhibition of L-type Ca2+ channels in vivo in wildtype and mutant mice by potent dihydropyridine (DHP) Ca2+ chann...

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Main Authors: Tamara Theiner (Author), Nadine J. Ortner (Author), Herbert Oberacher (Author), Gospava Stojanovic (Author), Petronel Tuluc (Author), Jörg Striessnig (Author)
Format: Book
Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
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