Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

• Asıl Yazarlar: Nils Ohnesorge (Yazar), Temitope Sasore (Yazar), Daniel Hillary (Yazar), Yolanda Alvarez (Yazar), Michelle Carey (Yazar), Breandán N. Kennedy (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Konular: article
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Unbiased screening of large randomized chemical libraries in vivo is a powerful tool to find new drugs and targets. However, forward chemical screens in zebrafish can be time consuming and usually >99% of test compounds have no significant effect on the desired phenotype. Here, we sought to find...