Matrix Vesicles: Role in Bone Mineralization and Potential Use as Therapeutics

• Main Authors: Sana Ansari (Author), Bregje W. M. de Wildt (Author), Michelle A. M. Vis (Author), Carolina E. de Korte (Author), Keita Ito (Author), Sandra Hofmann (Author), Yuana Yuana (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone is a complex organ maintained by three main cell types: osteoblasts, osteoclasts, and osteocytes. During bone formation, osteoblasts deposit a mineralized organic matrix. Evidence shows that bone cells release extracellular vesicles (EVs): nano-sized bilayer vesicles, which are involved in inte...