Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease

• Main Authors: Anna Daroszewska (Author), Lorraine Rose (Author), Nadine Sarsam (Author), Gemma Charlesworth (Author), Amanda Prior (Author), Kenneth Rose (Author), Stuart H. Ralston (Author), Robert J. van 't Hof (Author)
• Format: Book
• Published: The Company of Biologists, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paget's disease of bone (PDB) is an age-related metabolic bone disorder, characterised by focally increased and disorganised bone remodelling initiated by abnormal and hyperactive osteoclasts. The germline P392L mutation of SQSTM1 (encoding p62) is a strong genetic risk factor for PDB in humans...