Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease

• 主要な著者: Anna Daroszewska (著者), Lorraine Rose (著者), Nadine Sarsam (著者), Gemma Charlesworth (著者), Amanda Prior (著者), Kenneth Rose (著者), Stuart H. Ralston (著者), Robert J. van 't Hof (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2018-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Paget's disease of bone (PDB) is an age-related metabolic bone disorder, characterised by focally increased and disorganised bone remodelling initiated by abnormal and hyperactive osteoclasts. The germline P392L mutation of SQSTM1 (encoding p62) is a strong genetic risk factor for PDB in humans...