Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation

• Main Authors: Mitchell E. Granade (Author), Stefan R. Hargett (Author), Daniel S. Lank (Author), Michael C. Lemke (Author), Melissa A. Luse (Author), Brant E. Isakson (Author), Irina M. Bochkis (Author), Joel Linden (Author), Thurl E. Harris (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Adipose tissue is a critical regulator of energy balance that must rapidly shift its metabolism between fasting and feeding to maintain homeostasis. Adenosine has been characterized as an important regulator of adipocyte metabolism primarily through its actions on A1 adenosine receptors (...