Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases

• Main Authors: Naoe Kaneko (Author), Tomoyuki Iwasaki (Author), Yuki Ito (Author), Hiroyuki Takeda (Author), Tatsuya Sawasaki (Author), Shinnosuke Morikawa (Author), Naoko Nakano (Author), Mie Kurata (Author), Junya Masumoto (Author)
• Format: Book
• Published: BMC, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial role in interleukin-1 maturation or specific physiological functions. Two Nod-like r...