Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases

• Auteurs principaux: Naoe Kaneko (Auteur), Tomoyuki Iwasaki (Auteur), Yuki Ito (Auteur), Hiroyuki Takeda (Auteur), Tatsuya Sawasaki (Auteur), Shinnosuke Morikawa (Auteur), Naoko Nakano (Auteur), Mie Kurata (Auteur), Junya Masumoto (Auteur)
• Format: Livre
• Publié: BMC, 2017-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial role in interleukin-1 maturation or specific physiological functions. Two Nod-like r...