Add-on multiple submucosal injections of the RNA oligonucleotide GUT-1 to anti-TNF antibody treatment in patients with moderate-to-severe ulcerative colitis: an open-label, proof-of concept study

• প্রধান লেখক: Kenji Suzuki (লেখক), Yukinori Sameshima (লেখক), Junji Yokoyama (লেখক), Shuji Terai (লেখক), Hiroyuki Yoneyama (লেখক), Raja Atreya (লেখক), Markus F. Neurath (লেখক), Toshifumi Hibi (লেখক), Hitoshi Asakura (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: BMC, 2024-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background Carbohydrate sulfotransferase 15 (CHST15) is an enzyme biosynthesizing matrix glycosaminoglycan that modulates tissue remodeling. We evaluated the efficacy of add-on submucosal injections of GUT-1, the RNA oligonucleotide inhibitor of CHST15, to ongoing anti-tumor necrosis factor...