Add-on multiple submucosal injections of the RNA oligonucleotide GUT-1 to anti-TNF antibody treatment in patients with moderate-to-severe ulcerative colitis: an open-label, proof-of concept study

• Main Authors: Kenji Suzuki (Author), Yukinori Sameshima (Author), Junji Yokoyama (Author), Shuji Terai (Author), Hiroyuki Yoneyama (Author), Raja Atreya (Author), Markus F. Neurath (Author), Toshifumi Hibi (Author), Hitoshi Asakura (Author)
• Format: Book
• Published: BMC, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Carbohydrate sulfotransferase 15 (CHST15) is an enzyme biosynthesizing matrix glycosaminoglycan that modulates tissue remodeling. We evaluated the efficacy of add-on submucosal injections of GUT-1, the RNA oligonucleotide inhibitor of CHST15, to ongoing anti-tumor necrosis factor...