Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells

• Main Authors: Carina Lund (Author), Venkatram Yellapragada (Author), Sanna Vuoristo (Author), Diego Balboa (Author), Sara Trova (Author), Cecile Allet (Author), Nazli Eskici (Author), Kristiina Pulli (Author), Paolo Giacobini (Author), Timo Tuuri (Author), Taneli Raivio (Author)
• Format: Book
• Published: The Company of Biologists, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gonadotropin-releasing hormone (GnRH) neurons provide a fundamental signal for the onset of puberty and subsequent reproductive functions by secretion of gonadotropin-releasing hormone. Their disrupted development or function leads to congenital hypogonadotropic hypogonadism (CHH). To model the deve...