Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug combinations. Inspired by our previous efforts in designing antitumor evodiamine derivatives, herein selective histone deacetylase 1 (HDAC1)...

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Main Authors: Yahui Huang (Author), Shuqiang Chen (Author), Shanchao Wu (Author), Guoqiang Dong (Author), Chunquan Sheng (Author)
Format: Book
Published: Elsevier, 2020-07-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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