Enhanced Lactone Stability of CZ48 in Blood Correlates to its Lack of Toxicity in Mice

Enhanced Lactone Stability of CZ48 in Blood Correlates to its Lack of Toxicity in Mice

Purpose. The aim of this study was to correlate the relationship between the pharmacokinetic behaviors and the toxicity of a new investigational anticancer agent CZ48, a C20-propionate ester of camptothecin (CPT) in mice. Methods. In this study, the safety and pharmacokinetics of oral doses of CZ48...

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Main Authors: Xing Liu (Author), Yang Wang (Author), Zhisong Cao (Author), Max Zhan (Author), Dana Vardeman (Author), Beppino Giovanella (Author)
Format: Book
Published: Frontiers Media S.A., 2013-05-01T00:00:00Z.
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