Enhanced Lactone Stability of CZ48 in Blood Correlates to its Lack of Toxicity in Mice

• Главные авторы: Xing Liu (Автор), Yang Wang (Автор), Zhisong Cao (Автор), Max Zhan (Автор), Dana Vardeman (Автор), Beppino Giovanella (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2013-05-01T00:00:00Z.
• Предметы: article
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Purpose. The aim of this study was to correlate the relationship between the pharmacokinetic behaviors and the toxicity of a new investigational anticancer agent CZ48, a C20-propionate ester of camptothecin (CPT) in mice. Methods. In this study, the safety and pharmacokinetics of oral doses of CZ48...