Inflammatory signaling on cytochrome P450-mediated drug metabolism in hepatocytes

• Main Authors: Xiaokang Wang (Author), Jiaoyu Rao (Author), Zhiyi Tan (Author), Tianrong Xun (Author), Jingqian Zhao (Author), Xixiao Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome P450 (CYP450) enzymes are membrane-bound blood proteins that are vital to drug detoxification, cell metabolism, and homeostasis. CYP450s belonging to CYP families 1-3 are responsible for nearly 80% of oxidative metabolism and complete elimination of approximately 50% of all common clinica...