Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

• প্রধান লেখক: Elisa M. Crombie (লেখক), Seonyoung Kim (লেখক), Stuart Adamson (লেখক), Han Dong (লেখক), Tzu‐Chiao Lu (লেখক), Yiju Wu (লেখক), Yajun Wu (লেখক), Yotam Levy (লেখক), Nolan Stimple (লেখক), Wing Moon R. Lam (লেখক), Hwee Weng D. Hey (লেখক), Dominic J. Withers (লেখক), Ao‐Lin Hsu (লেখক), Boon Huat Bay (লেখক), Julien Ochala (লেখক), Shih‐Yin Tsai (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2023-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background Chronic mTORC1 activation in skeletal muscle is linked with age‐associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal muscle accelerates sarcopenia development in adult m...