Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability

• Main Authors: Juseung Lee (Author), Jong-Ju Lee (Author), Seungyeol Lee (Author), Linh Dinh (Author), Hangyu Oh (Author), Sharif Md Abuzar (Author), Jun-Hyun Ahn (Author), Sung-Joo Hwang (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)-a new anticoagulation drug-has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10⁻⁶ cm/s across Caco-2 colonic cells),...