Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability
(1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)-a new anticoagulation drug-has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10<sup>−6</sup> cm/s across Caco-2 colonic cells),...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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MDPI AG,
2023-03-01T00:00:00Z.
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