Mito-TIPTP Increases Mitochondrial Function by Repressing the Rubicon-p22phox Interaction in Colitis-Induced Mice

• Main Authors: Jae-Sung Kim (Author), Ye-Ram Kim (Author), Sein Jang (Author), Sang Geon Wang (Author), Euni Cho (Author), Seok-Jun Mun (Author), Hye-In Jeon (Author), Hyo-Keun Kim (Author), Sun-Joon Min (Author), Chul-Su Yang (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The run/cysteine-rich-domain-containing Beclin1-interacting autophagy protein (Rubicon) is essential for the regulation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by interacting with p22phox to trigger the production of reactive oxygen species (ROS) in immune cells. In a previous...