Inhibition of human carboxylesterases by ginsenosides: structure-activity relationships and inhibitory mechanism

• Main Authors: Zhao-Hui Sun (Author), Jing Chen (Author), Yun-Qing Song (Author), Tong-Yi Dou (Author), Li-Wei Zou (Author), Da-Cheng Hao (Author), Hai-Bin Liu (Author), Guang-Bo Ge (Author), Ling Yang (Author)
• Format: Book
• Published: BMC, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Human carboxylesterases (hCES) are key serine hydrolases responsible for the hydrolysis of a wide range of endogenous and xenobiotic esters. Although it has been reported that some ginsenosides can modulate the activities of various enzymes, the inhibitory effects of ginsenosides...