Two Innovative Approaches to Optimize Vancomycin Dosing Using Estimated AUC after First Dose: Validation Using Data Generated from Population PK Model Coupled with Monte-Carlo Simulation and Comparison with the First-Order PK Equation Approach

• المؤلفون الرئيسيون: Qingxia Liu (مؤلف), Huiping Huang (مؤلف), Baohua Xu (مؤلف), Dandan Li (مؤلف), Maobai Liu (مؤلف), Imam H. Shaik (مؤلف), Xuemei Wu (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The revised consensus guidelines for optimizing vancomycin doses suggest that maintaining the area under the concentration-time curve to minimal inhibitory concentration ratio (AUC/MIC) of 400-600 mg·h/L is the target pharmacokinetic/pharmacodynamic (PK/PD) index for efficacy. AUC-guided dosing appr...