Role of Estrogen Receptors α and β in a Murine Model of Asthma: Exacerbated Airway Hyperresponsiveness and Remodeling in ERβ Knockout Mice

• Autori principali: Rama Satyanarayana Raju Kalidhindi (Autore), Nilesh Sudhakar Ambhore (Autore), Sangeeta Bhallamudi (Autore), Jagadish Loganathan (Autore), Venkatachalem Sathish (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Epidemiological data suggests increased prevalence of asthma in females than males, suggesting a plausible role for sex-steroids, especially estrogen in the lungs. Estrogen primarily acts through estrogen-receptors (ERα and ERβ), which play a differential role in asthma. Our previous studies demonst...