Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors

• Main Authors: Kapil Gadkar (Author), Christina Friedrich (Author), Vincent Hurez (Author), Maria‐Luisa Ruiz (Author), Leslie Dickmann (Author), Mohit Kumar Jolly (Author), Leah Schutt (Author), Jin Jin (Author), Joseph A. Ware (Author), Saroja Ramanujan (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Several PI3K inhibitors are in clinical development for the treatment of various forms of cancers, including pan‐PI3K inhibitors targeting all four PI3K isoforms (α, β, γ, and δ), and isoform‐selective inhibitors. Diarrhea and immune‐mediated colitis are among the adverse events observed wi...