Application of a Physiologically Based Pharmacokinetic Approach to Predict Theophylline Pharmacokinetics Using Virtual Non-Pregnant, Pregnant, Fetal, Breast-Feeding, and Neonatal Populations

• Главные авторы: Khaled Abduljalil (Автор), Iain Gardner (Автор), Masoud Jamei (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Предметы: article
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Perinatal pharmacology is influenced by a myriad of physiological variables that are changing dynamically. The influence of these covariates has not been assessed systemically. The objective of this work was to use theophylline as a model drug and to predict its pharmacokinetics before, during (incl...