Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan

• Main Authors: Yuanzhi He (Author), Wei Zhang (Author), Tao Guo (Author), Guoqing Zhang (Author), Wei Qin (Author), Liu Zhang (Author), Caifen Wang (Author), Weifeng Zhu (Author), Ming Yang (Author), Xiaoxiao Hu (Author), Vikramjeet Singh (Author), Li Wu (Author), Ruxandra Gref (Author), Jiwen Zhang (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tremendous efforts have been devoted to the enhancement of drug solubility using nanotechnologies, but few of them are capable to produce drug particles with sizes less than a few nanometers. This challenge has been addressed here by using biocompatible versatile γ-cyclodextrin (γ-CD) metal-organic...