A New Computer Model for Evaluating the Selective Binding Affinity of Phenylalkylamines to T-Type Ca²⁺ Channels

• Main Authors: You Lu (Author), Ming Li (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To establish a computer model for evaluating the binding affinity of phenylalkylamines (PAAs) to T-type Ca²⁺ channels (TCCs), we created new homology models for both TCCs and a L-type calcium channel (LCC). We found that PAAs have a high affinity for domains I and IV of TCCs a...