Intestinal P‐gp activity is reduced in postmenopausal women under breast cancer therapy

• Main Authors: Joao Paulo B. Ximenez (Author), Jurandyr Moreira deAndrade (Author), Adriana Rocha (Author), Eduardo Barbosa Coelho (Author), Guilherme Suarez‐Kurtz (Author), Vera Lucia Lanchote (Author)
• Format: Book
• Published: Wiley, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Intestinal P‐glycoprotein (P‐gp) activity plays a crucial role in modulating the oral bioavailability of its substrates. Fexofenadine has commonly been used as a P‐gp probe, although it is important to note the involvement of other drug transporters like, OATP1B1, OATP1B3, and OATP2B1. In v...