Intestinal P‐gp activity is reduced in postmenopausal women under breast cancer therapy

• Hauptverfasser: Joao Paulo B. Ximenez (Verfasst von), Jurandyr Moreira deAndrade (Verfasst von), Adriana Rocha (Verfasst von), Eduardo Barbosa Coelho (Verfasst von), Guilherme Suarez‐Kurtz (Verfasst von), Vera Lucia Lanchote (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2024-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Intestinal P‐glycoprotein (P‐gp) activity plays a crucial role in modulating the oral bioavailability of its substrates. Fexofenadine has commonly been used as a P‐gp probe, although it is important to note the involvement of other drug transporters like, OATP1B1, OATP1B3, and OATP2B1. In v...