Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms

Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms

The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) refills the endoplasmic reticulum (ER) with Ca2+ up to the millimolar range and is therefore the main controller of the ER [Ca2+] level ([Ca2+]ER), which has a key role in the modulation of cytosolic Ca2+ signaling and ER-mitochondria Ca2+ transfer...

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Main Authors: Paloma García-Casas (Author), Jessica Arias- (Author), Pilar Alvarez-Illera (Author), Rosalba I. Fonteriz (Author), Mayte Montero (Author), Javier Alvarez (Author)
Format: Book
Published: Frontiers Media S.A., 2018-06-01T00:00:00Z.
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