Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms

• Prif Awduron: Paloma García-Casas (Awdur), Jessica Arias- (Awdur), Pilar Alvarez-Illera (Awdur), Rosalba I. Fonteriz (Awdur), Mayte Montero (Awdur), Javier Alvarez (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) refills the endoplasmic reticulum (ER) with Ca2+ up to the millimolar range and is therefore the main controller of the ER [Ca2+] level ([Ca2+]ER), which has a key role in the modulation of cytosolic Ca2+ signaling and ER-mitochondria Ca2+ transfer...