The Natural Flavone Acacetin Blocks Small Conductance Ca2+-Activated K+ Channels Stably Expressed in HEK 293 Cells

• Autores principales: Kui-Hao Chen (Autor), Hui Liu (Autor), Hai-Ying Sun (Autor), Man-Wen Jin (Autor), Guo-Sheng Xiao (Autor), Yan Wang (Autor), Gui-Rong Li (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The natural flavone acacetin inhibits several voltage-gated potassium currents in atrial myocytes, and has anti-atrial fibrillation (AF) effect in experimental AF models. The present study investigates whether acacetin inhibits the Ca2+-activated potassium (KCa) currents, including small conductance...