Glycyrrhetinic Acid-Functionalized Mesoporous Silica Nanoparticles for the Co-Delivery of DOX/CPT-PEG for Targeting HepG2 Cells

• Autori principali: Gabriel Martínez-Edo (Autore), Cristina Fornaguera (Autore), Salvador Borrós (Autore), David Sánchez-García (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2020-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

A pH-triggered mesoporous silica nanoparticle (MSN)-based nano-vehicle for the dual delivery of doxorubicin (DOX)/camptothecin-PEG (CPT-PEG) has been prepared. To enhance its selectivity, the nanoparticles were decorated with glycyrrhetinic acid (GA) to target HepG2 cells. The highly insoluble CPT w...