Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance

• Main Authors: Weihong Guo (Author), Lizhi Deng (Author), Jiang Yu (Author), Zhaoyu Chen (Author), Yanghee Woo (Author), Hao Liu (Author), Tuanjie Li (Author), Tian Lin (Author), Hao Chen (Author), Mingli Zhao (Author), Liming Zhang (Author), Guoxin Li (Author), Yanfeng Hu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug resistance is the major challenge facing cancer chemotherapy and nanoscale delivery systems based on natural materials, such as sericin, are a promising means of overcoming drug resistance. Yet, no attempt of introducing synthetic poly(γ-benzyl-L-glutamate) (PBLG) onto sericin polypeptide to fa...