Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons

• Main Authors: Dejie Chen (Author), Fenfei Gao (Author), Xiaokuang Ma (Author), Jason Brek Eaton (Author), Yuanbing Huang (Author), Ming Gao (Author), Yongchang Chang (Author), Zegang Ma (Author), Taleen Der-Ghazarian (Author), Janet Neisewander (Author), Paul Whiteaker (Author), Jie Wu (Author), Quanxi Su (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alpha6-containing nicotinic acetylcholine receptors are primarily found in neurons of the midbrain dopaminergic (DA) system, suggesting these receptors are potentially involved in drug reward and dependence. Here, we report a novel effect that cocaine directly inhibits α6N/α3Cβ2β3-nAChR (α6*-nAChRs)...