Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells.

• Main Authors: Stefanie Papp (Author), Kristin Moderzynski (Author), Jessica Rauch (Author), Liza Heine (Author), Svenja Kuehl (Author), Ulricke Richardt (Author), Heidelinde Mueller (Author), Bernhard Fleischer (Author), Anke Osterloh (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rickettsia (R.) typhi is the causative agent of endemic typhus, an emerging febrile disease that is associated with complications such as pneumonia, encephalitis and liver dysfunction. To elucidate how innate immune mechanisms contribute to defense and pathology we here analyzed R. typhi infection o...