Tissue Transglutaminase-Regulated Transformed Growth Factor-β1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis

• Main Authors: Juanjuan Tang (Author), Xunmin Zhu (Author), Jingjing Zhao (Author), Mingchiu Fung (Author), Yinyan Li (Author), Zhiyan Gao (Author), Suikai Yan (Author), Xiaomin Li (Author), Xiaofang Ji (Author), Fang Su (Author), Zi Li (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transforming growth factor (TGF-β1) is among the strongest factors of liver fibrogenesis, but its association with Schistosoma-caused liver fibrosis is controversial. Tissue transglutaminase (tTG) is the principal enzyme controlling TGF-β1 maturation and contributes to Sj-infected liver fibrosis. He...