Polygenic risk and incident coronary heart disease in a large multiethnic cohort

• Main Authors: Carlos Iribarren (Author), Meng Lu (Author), Roberto Elosua (Author), Martha Gulati (Author), Nathan D. Wong (Author), Roger S. Blumenthal (Author), Steven Nissen (Author), Jamal S. Rana (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Many studies support the notion that polygenic risk scores (PRS) improve risk prediction for coronary heart disease (CHD) beyond conventional risk factors. However, PRS are not yet considered risk-enhancing factor in guidelines. Our objective was to determine the predictive performance of...