Multivariate modeling of magnetic resonance biomarkers and clinical outcome measures for Duchenne muscular dystrophy clinical trials

• Main Authors: Sarah Kim (Author), Rebecca J. Willcocks (Author), Michael J. Daniels (Author), Juan Francisco Morales (Author), Deok Yong Yoon (Author), William T. Triplett (Author), Alison M. Barnard (Author), Daniela J. Conrado (Author), Varun Aggarwal (Author), Ramona Belfiore‐Oshan (Author), Terina N. Martinez (Author), Glenn A. Walter (Author), William D. Rooney (Author), Krista Vandenborne (Author)
• Format: Book
• Published: Wiley, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Although regulatory agencies encourage inclusion of imaging biomarkers in clinical trials for Duchenne muscular dystrophy (DMD), industry receives minimal guidance on how to use these biomarkers most beneficially in trials. This study aims to identify the optimal use of muscle fat fraction...