Epigenetic small-molecule screen for inhibition and reversal of acinar ductal metaplasia in mouse pancreatic organoids

• Hauptverfasser: Kalina R. Atanasova (VerfasserIn), Corey M. Perkins (VerfasserIn), Ranjala Ratnayake (VerfasserIn), Jinmai Jiang (VerfasserIn), Qi-Yin Chen (VerfasserIn), Thomas D. Schmittgen (VerfasserIn), Hendrik Luesch (VerfasserIn)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Schlagworte: article
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Background: Acinar ductal metaplasia (ADM) is among the earliest initiating events in pancreatic ductal adenocarcinoma (PDAC) development.Methods: We developed a novel morphology-based screen using organoids from wildtype and p48Cre/+ (Cre) mice to discover epigenetic modulators that inhibit or reve...