Epigenetic small-molecule screen for inhibition and reversal of acinar ductal metaplasia in mouse pancreatic organoids

• Main Authors: Kalina R. Atanasova (Author), Corey M. Perkins (Author), Ranjala Ratnayake (Author), Jinmai Jiang (Author), Qi-Yin Chen (Author), Thomas D. Schmittgen (Author), Hendrik Luesch (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Acinar ductal metaplasia (ADM) is among the earliest initiating events in pancreatic ductal adenocarcinoma (PDAC) development.Methods: We developed a novel morphology-based screen using organoids from wildtype and p48Cre/+ (Cre) mice to discover epigenetic modulators that inhibit or reve...