Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS)

• Main Authors: Mehran Ashfaq (Author), Shahid Shah (Author), Akhtar Rasul (Author), Muhammad Hanif (Author), Hafeez Ullah Khan (Author), Ahmed Khames (Author), Mohamed A. Abdelgawad (Author), Mohammed M. Ghoneim (Author), Muhammad Yasir Ali (Author), Mohammad A. S. Abourehab (Author), Safirah Maheen (Author), Omeira Iqbal (Author), Ghulam Abbas (Author), Amani M. El Sisi (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of the study was to develop an SNEDDS to improve the solubility and bioavailability of pitavastatin. The solubility of pitavastatin in different oils, surfactants, and co-surfactants was determined and a pseudo-ternary phase diagram was constructed. The SNEDDS was characterized by zeta-s...