Brachytherapy Approach Using ¹⁷⁷Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model

• Main Authors: Min-Ying Lin (Author), Hsin-Hua Hsieh (Author), Jyh-Cheng Chen (Author), Chuan-Lin Chen (Author), Nin-Chu Sheu (Author), Wen-Sheng Huang (Author), Shinn-Ying Ho (Author), Ting-Wen Chen (Author), Yi-Jang Lee (Author), Chun-Yi Wu (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brachytherapy can provide sufficient doses to head and neck squamous cell carcinoma (HNSCC) with minimal damage to nearby normal tissues. In this study, the β⁻-emitter ¹⁷⁷Lu was conjugated to DTPA-polyethylene glycol (PEG) decorated gold nanostars (<s...