No evidence for interactions of dimethylfumarate (DMF) and its main metabolite monomethylfumarate (MMF) with human cytochrome P450 (CYP) enzymes and the P‐glycoprotein (P‐gp) drug transporter

• Hlavní autoři: Jordi Aubets (Autor), Josep‐Maria Jansat (Autor), Miquel Salva (Autor), Vicky M. Birks (Autor), Richard J. Cole (Autor), Jenny Lewis (Autor), Annabell Pitcher (Autor), Michael Hall (Autor)
• Médium: Kniha
• Vydáno: Wiley, 2019-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Abstract Dimethylfumarate (DMF) has long been used as part of a fixed combination of fumaric acid esters (FAE) in some European countries and is now available as an oral monotherapy for psoriasis. The present investigation determined whether DMF and its main metabolite monomethylfumarate (MMF) inter...