HDAC1-mediated deacetylation of HIF1α prevents atherosclerosis progression by promoting miR-224-3p-mediated inhibition of FOSL2

• Main Authors: Hao Wang (Author), Kazuo Sugimoto (Author), Hao Lu (Author), Wan-Yong Yang (Author), Ji-Yue Liu (Author), Hong-Yu Yang (Author), Yue-Bo Song (Author), Dong Yan (Author), Tian-Yu Zou (Author), Si Shen (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We intended to characterize functional relevance of microRNA (miR)-224-3p in endothelial cell (EC) apoptosis and reactive oxygen species (ROS) accumulation in atherosclerosis, considering also the integral involvement of histone deacetylase 1 (HDAC1)-mediated hypoxia-inducible factor-1α (HIF1α) deac...