Development of a novel PROTAC using the nucleic acid aptamer as a targeting ligand for tumor selective degradation of nucleolin

• Үндсэн зохиолчид: Lin Zhang (Зохиогч), Ling Li (Зохиогч), Xia Wang (Зохиогч), Huimin Liu (Зохиогч), Yibin Zhang (Зохиогч), Tiantian Xie (Зохиогч), Hui Zhang (Зохиогч), Xiaodong Li (Зохиогч), Tianhuan Peng (Зохиогч), Xing Sun (Зохиогч), Jing Dai (Зохиогч), Jing Liu (Зохиогч), Wencan Wu (Зохиогч), Mao Ye (Зохиогч), Weihong Tan (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2022-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

PROteolysis TArgeting Chimeras (PROTACs) induce targeted protein degradation by hijacking the intracellular ubiquitin proteasome system, thus emerging as a new strategy for drug development. However, most PROTACs generated lack cell-type selectivity and are poorly soluble in water. To address this d...